Relaxant Effects of Rutin on Rat Smooth Muscles
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Abstract
The aim of the present study was to investigate the relaxant effects of rutin on rat thoracic aorta, ileum and trachea. Rutin (1X10-7 - 6X10-3 M) caused a concentration-dependent relaxation of aortic rings precontracted with phenylephrine (PE 10-6M) while produced non-significant relaxed effect on KCl induced contraction with Log IC50’s -3.025 and -2.885 M/ml respectively. Rutin exhibited potent inhibitory effects on (ACh 10-6 M) precontracted ileum of the rat with Log IC50 -5.996 M/mL. Rutin produced more potent inhibitory effect on ACh- than KCl-induced contractions in trachea, with Log IC50’s of -4.371 and -4.301 M/mL respectively. While rutin showed more potent inhibitory effect on PE-induced contractions potently than KCl precontracted aorta with Log IC50’s was -3.025 M and -2.885 respectively. From the data obtained during the present work, it can be concluded that rutin induces concentration-dependent relaxation in rat's smooth muscle. The mechanism of the relaxation may involves via nitric oxide-guanylyl cyclase pathway for aorta and anticholinergic activity for ileum and trachea.
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